A man smiling while hugging a young child who is also smiling

Let's protect our future

As parents, our greatest hope is to keep our children safe, healthy, and happy. It's completely normal to have questions—especially when it comes to decisions about their health. That's why we're here: to offer clear, compassionate, and trustworthy information about childhood vaccines.

This information is evidence-based and supported by an entire network of practicing pediatricians caring for families on a daily basis. Just think—this is something many of our own parents never had to question. But today, with so much information out there, it's okay to pause, ask questions, and learn.

The reality, before vaccines

1 in 5 children in the U.S. died before their fifth birthday

In the early 1900s, before vaccines were widely available, nearly 1 in 5 children in the U.S. died before their fifth birthday—often from infectious diseases we can now prevent. Measles, diphtheria, polio, and whooping cough were devastatingly common.

The positive impact

Vaccines are one of the most powerful tools in modern medicine—and one of the greatest public health success stories in history. Here’s what they’ve done:

Saved millions of lives

Vaccines prevent an estimated 4 million child deaths every year around the world. Between 2021 and 2030, they're expected to prevent over 50 million deaths globally. The measles vaccine alone has saved more than 90 million lives in the last 50 years—especially in regions like Africa and Southeast Asia, where access to care can be limited.

Past threats

Thanks to vaccines, diseases such as polio, measles, diphtheria, and Hib—which once caused widespread illness and death—are now rare or eliminated in the U.S. However, in communities with higher numbers of unvaccinated or under-vaccinated individuals, these diseases have started to reappear, sometimes leading to outbreaks.

polio

Polio

smallpox

Smallpox

diptheria

Diphtheria

measles

Measles

whooping-cough

Whooping cough

rotavirus

Rotavirus

pneumococcal

Pneumococcal

hib

Hib

hib

Chickenpox

Protecting
our children

Vaccines work with your child's natural defenses to build protection against serious diseases without them ever having to get sick.

Think of it like a training exercise for their immune system. Vaccination is one of the best ways to protect your child from serious diseases.

When a germ enters your body, your immune system learns to fight it. Vaccines introduce a tiny, harmless part of a germ, or a weakened form of it, to your child's immune system.

Concerns you have

Many parents have similar questions. Let’s walk through some of the most common concerns:

Are vaccines safe? I've heard about serious side effects.

Vaccine safety is the top priority in the medical community. Before any vaccine is approved, it goes through many years of careful testing by scientists and doctors. Once approved, its safety is continuously monitored.

Serious side effects from vaccines are very rare but minor side effects, like a sore arm or a low-grade fever, are common and show that your child's immune system is building protection.

Hundreds of millions of doses of vaccines have been administered in the United States and the safety record is excellent.

The vaccine schedule has increased dramatically since I was born

It's true—children do receive more vaccines now than in the past. That’s because medical science has developed safe and effective vaccines to prevent illnesses that once caused serious complications, hospitalizations, and even death. Diseases like meningitis, pneumonia, and sepsis are now far less common thanks to newer vaccines such as pneumococcal, meningococcal, and Haemophilus influenzae type b (Hib), which were introduced after many of us were children. The current schedule is built on decades of research to ensure children are protected at the ages when they are most at risk.

I'm worried about vaccine ingredients.

Vaccine ingredients are present in very small, safe amounts, often less than what your body naturally produces or encounters in daily life. Misinformation about ingredients can be scary. The scientific consensus is clear: the trace amounts of these ingredients in vaccines are safe and necessary to make the vaccines work effectively. The potential harm from these trace ingredients is infinitely smaller than the proven dangers of the diseases they prevent but we understand that this complicates the decision for parents.

Why give them so many vaccines at once?

The tiny amounts of antigens (the parts of the germ that trigger an immune response) in vaccines are far less than what a child encounters naturally.

Giving many vaccines at once helps protect kids from sickness when they are most likely to get sick, and when it's safe to give the shots. Getting them together or separately doesn't change how often kids have side effects. Also, vaccines that combine several protections are tested together to make sure they still work well and don't cause more side effects.

These diseases are so rare now, do my children really need vaccines? I only want the most necessary vaccines.

It's a common and understandable thought, but it's a bit like saying, "we don't need seatbelts anymore because car accidents are less common." The safety comes from the protective measure. The reason these diseases are rare is because of vaccines. If we stop vaccinating, these diseases can quickly return. We've seen this happen with measles outbreaks in communities with low vaccination rates.

For example, in 2025, the United States experienced its largest measles outbreak in more than 30 years, with over 760 cases in Texas alone. Nearly 96% of those affected were under-immunized, leading to more than 170 hospitalizations—including one in five children under the age of five.

I believe in natural remedies.

While a healthy lifestyle is important, it cannot fully protect against highly contagious and dangerous diseases like measles or polio. Vaccines train your immune system to recognize and fight off specific viruses and bacteria that can cause severe illness, something natural remedies cannot replicate. The historical data on childhood deaths before vaccines clearly shows that a strong immune system alone was not enough to prevent widespread illness and death from these diseases.

Do vaccines cause autism?

This is one of the most common questions parents ask. The short answer is no—vaccines do not cause autism. The idea started in 1998 with a small study involving only 12 children that suggested a link between the MMR (measles, mumps, rubella) vaccine and autism. That study was later proven to be fraudulent, retracted by the medical journal, and the author lost his medical license. Since then, researchers all over the world have looked closely at this question. Large studies following hundreds of thousands, and even millions of children show the same result, that there is no connection between vaccines and autism.

  • In Denmark, a study of over 650,000 children found no difference in autism rates between vaccinated and unvaccinated kids (Hviid et al., Ann Intern Med, 2019).
  • A review of studies involving more than 1.2 million children also found no link (Taylor et al., Vaccine, 2014).
  • Most recently, in 2025, a new Danish study of 1.2 million children looked at 50 different health outcomes—including autism—and again found no increased risk from vaccines or vaccine ingredients (Statens Serum Institut, Ann Intern Med, 2025).

We now know that autism begins very early in brain development, often before a baby is even born. Genetics play the biggest role. Autism is often diagnosed around the same time that children get certain vaccines. That timing, combined with misinformation, fuels the myth. Vaccines are safe, effective, and one of the best ways we have to protect children.

A clear path to protection

The childhood vaccine schedule is developed by leading medical experts, including pediatricians, and carefully reviewed each year to ensure it provides the best protection for your child. It's designed to protect them at the earliest age possible when they are most vulnerable to these serious diseases.

Trusted leaders in the American Academy of Pediatrics, the American Academy of Family Physicians, and the Centers for Disease Control and Prevention all strongly support protecting children with recommended vaccinations. They practice what they preach—all of these physicians follow the vaccine schedule for their own children and families.

Recommended for all infants and children

Recommended only for infants/children with certain medical conditions or risk factors

Talk to your healthcare provider to decide if this vaccine is right for your teenager

Vaccine or Preventive Antibody 2-4
Weeks
2
Months
4
Months
6
Months
9
Months
12
Months
15
Months
18
Months
2
Years
4-5
Years
9
Years
11
Years
16
Years
TYPICAL #
OF SHOTS*
0 2 2 2 0 3 2 1 0 3 1 3 2
HepB
Dose 1
Dose 2
Dose 3
DTaP
Dose 1
Dose 2
Dose 3
Dose 4
Dose 5
Polio
Dose 1
Dose 2
Dose 3
Dose 4
Dose 5
Hib
Dose 1
Dose 2
Dose 3
Dose 4
Pneumococcal
Dose 1
Dose 2
Dose 3
Dose 4
Rotavirus**
Dose 1
Dose 2
Dose 3
MMR
Dose 1
Dose 2
Chickenpox
Dose 1
Dose 2
HepA
Dose 1
Dose 2
Tdap
Dose 1
MenACWY
Dose 1
Dose 2
HPV
2 doses
MenB
2 doses
RSV
First RSV season
Second RSV season
Flu
Every season
COVID-19
Every season
Every season

*This schedule shows the typical number of vaccines at each age when combination vaccines are used (which help reduce the number of separate shots). It assumes your child is following the recommended schedule and is up to date.

Infants should receive protection against RSV during their first RSV season, and all children should receive flu vaccine once they are over 6 months old. Some infants with high-risk conditions may need additional RSV protection during their second season and COVID-19 vaccination when eligible.

** Rotavirus is given orally, not as a shot.

Understanding the different diseases

Knowing what to expect

It's completely normal for your child to feel a little discomfort after getting vaccinated. This is usually a sign that their immune system is working and building protection. Knowing what to expect and how to help can make the experience easier for both of you.

Fever

A low-grade fever means your child's immune system is "turned on." This may be because the vaccine is working or because the child has an infection.

Check your child's temperature (a fever is 100.4°F (38°C) or higher).

You can give acetaminophen (like Tylenol) or ibuprofen (like Advil or Motrin) for fever and always base the dose on your child's weight and your healthcare provider's instructions.

Give your child plenty of fluids and dress them lightly.
Do not cover or wrap your child tightly.

Soreness, redness, or swelling where the shot was given

Put a clean, cool, wet washcloth over the sore area for comfort. Do this for 10 minutes, 3 times a day.

Check the site daily. If it's not improving after 1-2 days, call your healthcare provider.

While serious side effects are rare, it's important to know when to seek immediate medical advice. If your child seems very ill, seek medical advice from your healthcare provider.

Get in touch

VaxFacts is a trusted online resource, meticulously compiled by a network of nationally respected pediatricians. It serves as a reliable source for comprehensive and evidence-based vaccine information in the U.S.